I know they searched it as soon as he was arrested in 2019 and they had to use a saw to get into the safe.
https://www.businessinsider.com/fbi-used-saw-open-jeffrey-epstein-safe-hard-drives-diamonds-2021-12
FBI agents used a saw to open a locked safe kept in the Manhattan mansion of the deceased sex offender Jeffrey Epstein, the agent who led the FBI search team said at Ghislaine Maxwell's trial on Monday. Inside the safe, the FBI special agent said, the officers found hard drives, CDs, diamonds, and passports belonging to Epstein.
Federal prosecutors previously alluded to the contents of the safe in 2019, when they sought to have a judge deny Epstein's bail application later that month. They said agents found $70,000 in cash, 48 loose diamonds and other jewelry, and a passport from a foreign country with a picture of Epstein under another name in the safe.
Joseph Recarey, a Florida detective who executed a search warrant on Epstein's Palm Beach home as part of an investigation in 2005, said hard drives had gone missing shortly before officers entered the home. Epstein later pleaded guilty to solicitation charges in connection with that investigation.
"Six computer hard drives in the house had been hastily removed, leaving dangling wires attached to monitors in several areas of the house," Recarey told the Miami Herald investigative reporter Julie K. Brown for her book "Perversion of Justice." It's unclear if these are the same hard drives.
They searched the Island as soon as he died. I don't know when they searched the other properties.
For whatever it's worth, according to Google's AI overview, there was no secret space.
AI Overview
There were reports and speculation about a "secret space" within Jeffrey Epstein's Manhattan mansion, but no confirmed evidence of a hidden, secret apartment or room. The mansion was described as having a "respectable veneer" but with a mysterious and potentially sordid interior, according to The Times.
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