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NNadir

(36,187 posts)
12. That sounds like a nasty syndrome. I never heard of it, but looked it up.
Mon Jun 30, 2025, 10:12 PM
Jun 30

It seems to be an autoimmune disease from a cursory look at this paper:

Maverakis, E., Marzano, A.V., Le, S.T. et al. Pyoderma gangrenosum. Nat Rev Dis Primers 6, 81 (2020)

When I called this paper up and downloaded it - unfortunately it requires access, which I have, but it is not generally open to the public - I came across another paper that is open access:

Moura, R.R., Brandão, L., Moltrasio, C. et al. Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease. Sci Rep 13, 4919 (2023)

It probably requires a modicum of scientific knowledge to understand the paper, but if I can say anything, we do live (or have lived, as science is being actively attacked) in the golden age of molecular biology, particularly with respect to immunology, and I hope and suspect that your daughter's return to work is an outgrowth of such knowledge.

I have been around lupus patients in connection with a family I knew when I was a young man, a similar (from what I can tell) autoimmune disease, and from that, I know it can be rough.

I'm sure I speak for everyone here in wishing you and your daughter the best.

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