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Science

mr715

(4,067 posts)

4. Tryptophan hydroxylase.

Reply to NNadir (Reply #3)

Fri May 8, 2026, 11:53 PM

Friday

Not insertion. Knock-out.

Disrupting the serotonin synthesis pathway in the central nervous system. Pure science objective of understanding what serotonin really does. Applied science goal of developing novel methods to decrease mosquito host-seeking to prevent disease transmission.

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I successfully used crispr to edit mosquitoes! [View all] mr715 Friday OP

My bug zapper does that too! erronis Friday #1

The handheld ones are very satisfying. mr715 Friday #2

Cool. What kind of gene did you insert? NNadir Friday #3

Tryptophan hydroxylase. mr715 Friday #4

That my friend, is very cool. I have to say that tryptophan has always been one of my favorite amino acids, probably... NNadir Saturday #5

It is amazingly well conserved. mr715 Saturday #6

Very cool. By "HELL" you mean histidine-glutamic acid-leucine-leucine or something else? NNadir Saturday #7

Yeah. mr715 Saturday #8

Cool. Do you happen to have the Uniprot accession number? I'd like to look into this one, nonprofessional interest... NNadir Saturday #9

Here is a link to it in uniprot mr715 Saturday #10

Very cool. I like your advisor's wit. Into what species of mosquito did you knock out the gene? NNadir Saturday #11

Yes, it has a fully sequenced genome. mr715 Saturday #12

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