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Science

NNadir

(38,475 posts)

9. Cool. Do you happen to have the Uniprot accession number? I'd like to look into this one, nonprofessional interest...

Reply to mr715 (Reply #8)

Sat May 9, 2026, 12:30 AM

Yesterday

...just because, well, just because...

I'm a mass spec kind of person as far as proteomics goes, and I often find myself contemplating sequences across species, as I have been peripherally involved in gene modification for genetic diseases. It comes up when one is inserting a human gene in a monkey to experiment in preclinical trials with treating genetic syndromes.

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I successfully used crispr to edit mosquitoes! [View all] mr715 Friday OP

My bug zapper does that too! erronis Friday #1

The handheld ones are very satisfying. mr715 Friday #2

Cool. What kind of gene did you insert? NNadir Friday #3

Tryptophan hydroxylase. mr715 Friday #4

That my friend, is very cool. I have to say that tryptophan has always been one of my favorite amino acids, probably... NNadir Yesterday #5

It is amazingly well conserved. mr715 Yesterday #6

Very cool. By "HELL" you mean histidine-glutamic acid-leucine-leucine or something else? NNadir Yesterday #7

Yeah. mr715 Yesterday #8

Cool. Do you happen to have the Uniprot accession number? I'd like to look into this one, nonprofessional interest... NNadir Yesterday #9

Here is a link to it in uniprot mr715 Yesterday #10

Very cool. I like your advisor's wit. Into what species of mosquito did you knock out the gene? NNadir Yesterday #11

Yes, it has a fully sequenced genome. mr715 22 hrs ago #12

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